Jenner, Edward, regimen prior to variolation, 45; birth and edu- cation, 91; relations with John Hunter, 92-93; Sodbury legend, 93; a bore about cowpox, 95; miraculous prevision, 95; Gardner's questionable remi- niscences, 97, 122; horse with greasy heels the origin of small- pox, 97, 359; marriage in 1788, 97; a good hand at verses, 97; purchase of degree from St. Andrews, 98; inoculates son with swinepox, 98; experi- ments with cowpox, 98-99; origin of cowpox in horsegrease beyond denial, 100; difficulty of proof, 100.
First vaccination, 1796, 101; publishes Inquiry, 1798, 102; describes cowpox, 109; tries in vain to generate it from horse- grease, 110 - 112; invents spurious cowpox, 113; denies virtue for cowpox and asserts it for horsegrease cowpox, 114; cases of horsegrease, 115; fancy as to origin of smallpox, 120, 359, 513; absolute security from smallpox after horse- grease cowpox, 121; cowpox as an expulsive irritant, 123; single point of originality, 124; visit to London, 1798, 127; without cowpox, 129; advised by Cline to settle in London, 129; difference with Ingen- housz, 130-132; favourable reception of Inquiry, 134; Pearson claims association, 134; brickbats flying around, 135; cowpox always erysi- pelatous, 143; uses cowpox from London, 147; jealousy of Pearson, 147; inquiries at a stand, 148; visits London to counteract Pearson and Wood- ville, 148; anxious, fretful, helpless, 151; Further Obser- vations, 1799, 152; purpose and poverty of pamphlet, 152;
differences with Pearson and Woodville, 158; slovenly and incomplete knowledge, 158; Vaccine Pock Institution, 160- 161; Continuation of Facts and Observations, 1800, 163; annex- ation of Pearson and Wood- ville's work, 163-164, 181; re-asserts the abiding prophy- laxy of cowpox, 166; tries to undermine Vaccine Pock Insti- tution, 167; reception by King and Queen, 171; John Ring's alliance, 172, 176; presented with plate, 1801, 176; finds honour windy fare, 177; deter- mines to drop horsegrease, 178, 180; mode of transforma- tion, 178; Origin of the Vaccine Inoculation, 1801, 178; claims discovery of cowpox, 179, and discriminates true from spurious, 180; artful explana- tions, 182-183; application to Lord Sherborne, 183; prepares petition, 184-185, which is re- ferred to committee of House of Commons, 186; evidence before committee, 186-194; claim limited to conveyance of cowpox from arm to arm, 193; voted £10,000 by House of Commons, 196.
Jenner's case examined by Pearson, 197-203; could he have taken a patent? 207; factitious glory, 215; delay in payment of £10,000, 216; fate as London physician, 216; Royal Jennerian Society, 218- 219; head turned with adula- tion, 221; uxorious habits, 222; quarrel with Walker, 225-226; wreck of Royal Jennerian Society, 227; impe- cuniosity, 228; shyness, 230; "the cowpox doctor," 230; plans for pecuniary relief, 231; reference of Parliament to Royal College of Physicians, 232-234; Jenner's evidence
and disownment of spurious cowpox, 239 240; voted £20,000, 243-248; director of National Vaccine Establish- ment, 255; withdraws and ex- pects sensation, 256; sulking at Berkeley, 257; tactics as to horsegrease, 259, 262, 263; what did he discover? 261; swinepox, 262; reverts to original position, 264, 267; uses and diffuses horsepox, 268-269; a slovenly investi- gator, 270, 272; Birch on spurious cowpox, 277-278; pestered with failures, 280-281; Birch "a sad wicked fellow," 283; treatment of Goldson, 285; claim to absence of fail- ures, 287; friendship with Rev. Rowland Hill, 294.
Miraculous quality of Jen- ner's contempt, 301; split with Walker, 307; vaccinates sons of Sir Richard Phillips and Philip Codd, who afterwards had smallpox, 312-313; also of Earl Grosvenor, 318-321; the slush his followers had to march through,315; dislike of Walker and his Institution, 324; Ring as bully and libeller, 324-330; Jenner's later writings, 333- 348; why Inquiry was sup- pressed, 333-337; mystery of horsegrease, 334-336; experi- ments with horsegrease on cows, 335; spurious cowpox dodge, 336; herpes and vacci- nation, 340-342; elusion of variolous test, 342; smallpox flying in all directions, 344- 345; comparative London mortalities, 346; successive poxes for vaccination, 347-348, 525; final publication on Tar- tar Emetic, 348; Baron's bio- graphy, 349-363; meeting with Baron, 349-350; treatment of adversaries, 350 - 352, 474; investigation resented, 352;
appropriation of work of others, 352-353; denial that influence of vaccination wore out, 353; Lord Ellenborough, 353-354, 357; dying testimony to vaccination, 354; contri- vances to break his fall, 355- 356; variolation of son and scandal, 357-358; insanitary house and sickly family, 85, 318, 358-359, 448; belief that human diseases originated in animals, 97, 359; suggested extension of vaccination, 359- 360; much adulation excused self-deception,360; abhorrence of London, 361; exclusion from Royal College of Physicians, 361; presentation to Emperor Alexander, 362; death of Mrs. Jenner, 1815, 362; perplexities toward close of life, 362; death, 1823, 362; funeral and me- morials, 363; statue in London, 363; sends equine virus to Edinburgh, 368, tactics as con- cerned horsegrease, 375; sends gold box to Dr. Waterhouse, 378; project and reward for conveyance of virus to India, 383-384; vaccination in Madras and Bombay, 388; tribute from India,390; Sweden and Ceylon, 392; medal from naval officers, 398; anecdote of Napoleon, 400.
Arithmetical incapacity, 415, 423; reason for vote of £20,000, 453; denial of spurious cowpox, 454; deceived as to National Vaccine Establish- ment, 454 456; insolence to- ward Brown of Musselburgh, 457-458; his virus the stock of National Vaccine Establish- ment, 472-473; treatment of opponents, 474; did not intro- duce cowpox, 512; smallpox from horse through cow, 513; vaccinates King's staghounds, 515; ruthless, untruthful, mercenary, 578.
PUBLICATIONS ON VACCINATION AND SUCCESSIVE ASSURANCES.
An Inquiry into the Cause and Effects of the Variola Vaccinæ, a Disease discovered in some of the Western Counties of Eng- land, particularly Gloucestershire, and known by the name of the Cow Pox. London: 1798.
1798.-What renders the Cow Pox Virus so extremely singular is, that the person who has been thus affected is for ever after secure from the infection of the Small Pox; neither the exposure to the variolous effluvia, nor the insertion of the matter into the skin, producing this distemper.
It is curious to observe, that the virus, which with respect to its effects is undetermined and uncertain previously to its passing from the horse through the medium of the cow, should then not only become more active, but should invariably and completely possess those specific properties which induce in the human constitution symptoms similar to those of the variolous fever, and effect in it that peculiar change which for ever renders it unsusceptible of the variolous contagion. It clearly appears that this disease leaves the constitution in a state of perfect security from the infection of the Small Pox.-Pp. 121, 337.
Further Observations on the Variola Vaccinæ. London: 1799. 1799. The result of all my trials with the virus on the human subject has been uniform. In every instance the patient who has felt its influence has completely lost the susceptibility for the variolous contagion.-Pp. 152-158, 336.
A Continuation of Facts and Observations relative to the Variola Vaccine, or Cow Pox. London: 1800.
1800. The scepticism that appeared even among the most enlightened of medical men, when my sentiments on the important subject of the Cow Pox were first promulgated, was highly laudable. To have admitted the truth of a doctrine, at once so novel and so unlike anything that had ever appeared in the Annals of Medicine, without the test of the most rigid scrutiny, would have bordered upon temerity; but now, when that scrutiny has taken place, not only among ourselves, but in the first professional circles in Europe, and when it has been uniformly found in such abundant instances, that the human frame, when once it has felt the influence of the genuine Cow Pox in the way that has been described, is never afterwards, at any period of its existence, assailable by the Small Pox, may I not with perfect confidence congratulate my country and society at large on their beholding in the mild form of the Cow Pox, an antidote that is capable of extirpating from the earth a disease which is every hour devouring its victims; a disease that has ever been considered as the severest scourge of the human race. Pp. 166, 338-339, 357, 365, 473.
The Origin of Vaccine Inoculation. London: 1801.
1801.-It now becomes too manifest to admit of controversy, that the annihilation of the Small Pox, the most dreadful scourge of the human species, must be the final result of this practice.-P. 183.
Petition for Remuneration to House of Commons. 1802. 1802.--Cow Pox admits of being inoculated on the human frame with the most perfect ease and safety, and is attended with the singularly beneficial effect of rendering through life the persons so inoculated perfectly secure from the infection of the Small Pox.- Pp. 184, 337, 355.
On the Varieties and Modifications of the Vaccine Pustule occasioned by an Herpetic State of the Skin. Printed in Medi- cal and Physical Journal, August, 1804; and reprinted as a pamphlet, Cheltenham, 1806, and Gloucester, 1819.-P. 340.
VACCINATION EQUAL TO VARIOLATION.
1804.-What I have said on Vaccination is true. If properly conducted it secures the constitution as much as Variolous Inoculation possi- bly can.-Baron's Life of Jenner, vol. ii. p. 15.
Duly and efficiently performed, Vaccination will protect the constitu- tion from subsequent attacks of Small Pox as much as that disease itself will. I never expected that it would do more, and it will not, I believe, do less.-Ibid. p. 135.
1806. The security given to the constitution by Vaccine Inoculation is exactly equal to that given by the Variolous. To expect more from it would be wrong. As failures in the latter are constantly presenting themselves, we must expect to find them in the former also.-Letter to Richard Dunning, 1st March, 1806.-Pp. 339, 355.
Facts for the most part unobserved or not duly noticed res- pecting Variolous Contagion. London: 1808.
1808. It should be remembered that the constitution cannot, by previous infection, be rendered totally insusceptible of the Variolous Poison. Neither the casual, nor the inoculated Small Pox, whether it produce the disease in a mild or violent way, can perfectly extinguish the susceptibility.-P. 338.
Letter to William Dillwyn on the Effects of Vaccination in . Preserving from the Small Pox. Philadelphia: 1818. 1818. My confidence in the efficacy of Vaccination to guard_the constitution from Small Pox is not in the least diminished. That
. exceptions to the rule have appeared, and that they will appear, I am ready to admit. They have happened after Small Pox Înocula- tion; and by the same rule, as the two diseases are so similar, they will also happen after Vaccine Inoculation.-P. 344.
1823. My opinion of Vaccination is precisely as it was when I first promulgated the discovery. It is not in the least strengthened by any event that has happened, for it could gain no strength; it is not in the least weakened; for if the failures you speak of had not happened, the truth of my assertions respecting those coincidences which occasioned them would not have been made out.-P. 354. The whole of Jenner's claims re-asserted for Smallpox Cowpox by Mr. John Simon, after Inoculation with which-
1857.-"Neither renewed vaccination, nor inoculation with Smallpox, nor the closest contact and cohabitation with smallpox patients, will occasion him to betray any remnant of susceptibility to infec- tion."-Papers relating to the History and Practice of Vaccination. London: 1857.-P. 513.
JENNER'S SUCCESSIVE POXES
In their order, 124, 185, 207, 240, 334-338, 347-348, 472-473, 512-513. Cowpox, first faith, 93-95, 99, 114, 334.
Cowpox did not prevent smallpox, 99, 113, 143, 179, 201, 347, 512. Horsegrease, 97, 99-100, 104, 124, 142, 273, 335.
Spurious Cowpox defined, 99, 113-114.
Horsegrease Cowpox, 100, 110-114, 119-121, 124-125, 153-155, 198, 201, 259-274, 335, 375.
Horsegrease dropped, 178-180, 201-203, 260, 266, 375. Cowpox resumed, 180-183, 202-203, 512.
Spurious Cowpox dropped, 239-240, 277-278, 314, 336, 356, 454. Horsegrease or Horsepox adopted neat, 229, 264-273; the true and genuine life-preserving fluid, 269; equine virus sent to Edinburgh, 368. Sacco's practice, 264, 267, 336, 512, and De Carro's, 265, 405.
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