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CORPORA LUTEA NOW AVAILABLE. Physicians who have been desirous of prescribing corpora lutea, but have been unable to do so through inability of their druggists to supply it, will be glad to know that the manufacturers, Messrs. Parke, Davis & Co., have taken steps to secure sufficient quantities of the glands in the future to meet the probable demands of the medical profession.

As is known, perhaps, to most physicians, corpora lutea is largely used to control the symptoms following the removal of the ovaries, especially in young women, and to relieve the nervous disturbances attending the natural menopause. Reports have appeared on its successful employment in the of amenorrhea, dysmenorrhea, chlorosis and menorrhagia. It is supplied in It is supplied in desiccated form, in capsules of five grains each, equivalent to about thirty grains of fresh corpus luteum. Only the yellow granular material from fresh ovaries is used in its preparation, the remainder of the gland being discarded because of its lack of therapeutic value.

While comparatively a new product, there is sufficient evidence at hand to warrant the opinion of one writer who expresses the belief that "in corpora lutea we have a preparation that will be a blessing to womankind."

A SYSTEMIC BOOST.

It is safe to say that the average physician is called upon to prescribe a tonic more frequently than any one other form of medication, unless it be a cathartic. Patients who are patients solely because they are tired, "run down" and generally debilitated, are constant visitors at the physician's office. Such individuals need something that will boost them up to their normal point of resistance and then hold them there: in other words, not a mere temporary stimulation, with secondary depression, but a permanent help to the revitalization of the blood and a general reconstruction.

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THE IDEAL ELIMINATIVE.

The cause of rheumatism is as certain, as definite, and as well defined as that of malaria or syphilis. The cause of all forms of rheumatism that I have ever seen has been deficient elimination, principally manifested by the urinary solids falling to a point far below normal.

All of the most valuable rheumatic remedies, those most prompt, reliable and uniform in their action, are active stimulants of elimination, and cause a decided increase in the solid matter carried off by the urine.

Tongaline, by its highly stimulating action on the liver, the bowels, the kidneys and the pores, is the "ideal eliminative" and has no equal in the treatment of rheumatism, neuralgia, grippe, gout, nervous headache, malaria, sciatica, lumbago, tonsilitis, heavy colds and excess of uric acid.

PROPHYLAXIS AGAINST GRIPPAL
ATTACKS.

If many who become subject to grippal attacks, had but increased the resistance of their tissues to germ invasion, they might have been spared such attacks. It is for such a purpose that Cord. Ext. Ol. Morrhuæ Comp. (Hagee) shows its pronounced worth. For patients who are debilitated and who might easily become victims of grip, Cord. Ext. Ol. Morrhuæ Comp. (Hagee) is of utmost value as a strengthening agent. It makes new blood and puts added resistance in the tissues.

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VASO-MOTOR DERANGEMENTS.

The part played by the vaso-motor system in countless diseases is at last thoroughly recognized. As a consequence, circulatory disorders are among the most common functional ailments that the modern physician is called upon to correct. Various heart tonics and stimulants are usually employed, but the effect of these is rarely more than temporary. To re-establish a circulatory equilibrium that offers real and substantial relief from the distressing symptoms that call most insistently for treatment requires a systematic building up of the whole body. Experience has shown that no remedy at the command of the profession is more serviceable in this direction than Gray's Glycerine Tonic Comp.

For nearly 20 years this standard tonic has filled an important place in the armamentarium of the country's leading physicians. Its therapeutic efficiency in restoring systemic vitality and thus overcoming functional disorders of the vaso-motor or circulatory system is not the least of the qualities that account for its widespread use. The results, however, that can be accomplished in many cases of cardiac weakness have led many physicians to employ it almost as a routine remedy at the first sign of an embarrassed or flagging circulation.

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A SAFE AND RELIABLE ANALGESIC.

It is difficult to find an efficient remedy for the relief of pain which at the same time produces no narcotic effects with their distressing and oftentimes disastrous sequelæ. For this reason the opiates, effective as they may be in soothing pain, are usually contraindicated. A habit may be induced which in many instances it is impossible to break. Phenalgin, however, controls pain with remarkable efficacy and because of its composition is free from all danger of causing a drug habit. Since it possesses the therapeutic remedies of the narcotising agents without their drawbacks it has a wide field of use. Phenalgin is especially indicated for the relief of dysmenorrhea, from which so many women, from the sedentary nature of their employment suffer nowadays. When these periodical pains recur, the victim is apt to fly to a narcotic to gain a respite, and the consequence too often is that a drug habit is formed. Through the use of phenalgin, however, the practitioner can promptly control painful menstruation with gratifying avoidance of all tendencies to drug habituation. Equal confidence may be placed in the use of phenalgin in other conditions. Thus in the treatment of alcoholism, phenalgin may be relied on to relieve the unpleasant symptoms and to restore the victim to normal condition in a

The Meaning of Substitution to the Physician.

The substitutor prescribes for your patient without regard to your reputation or the welfare of your patient, assuming that you do not know your business Why does he do it? For illegitimate profit. What are you going to do about it?

natural manner. In fact, in all disorders or diseases in which pain is a prominent symptom, such as cephalagia, gastro-intestinal complaints, la grippe, rheumatism, lumbago, malaria, neuralgia, neurasthenia and gout, phenalgin affords prompt and satisfactory relief, without locking up the secretions or causing constipation.

UTERO-OVARIAN NEUROSES.

The nervous attacks and minor attacks of pain which arise from functional disturbance in the utero-ovarian tract, furnish a splendid field for Pasadyne (Daniel) and show in a gratifying fashion the marked usefulness of this product in nervous attacks and even as a mild anodyne. A particularly valuable point about Pasadyne (Daniel) is its freedom from danger. As is well known, Pasadyne (Daniel) is the distinctive name for a pure concentrated tincture of passiflora incarnata. A sample bottle may be had by addressing the laboratory of John B. Daniel, 34 Wall Street, Atlanta, Georgia.

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SEXUAL NEUROSES.

Whilst it is true that in many instances a definitely existing lesion somewhere along the genitourinary tract is the underlying cause of that distressing condition popularly described as sexual neurasthenia, yet in certain cases it is impossible of detection, or if detected its effects are too firmly fixed to make an immediately favorable response to the local treatment instituted. Wherefore the need for a soothing agent such as Bromidia (Battle) becomes necessary. In cases of this character with marked nervous involvement Bromidia (Battle) is of the greatest service. It soothes the sexual irritability and enables the patient to rest and sleep well.

GLYCO-THYMOLINE FOR COLDS.

At this season of the year the crop of "colds" becomes very numerous.

One of the first efforts of the physician aims at relieving the congestion of the nasal mucous membrane and bringing some degree of comfort to his patient.

Glyco-Thymoline in a 25 per cent solution used in connection with the K. & O. Nasal Douche, not only cleanses the nasal passages of the mucous secretions but also reduces the congestion by its exosmotic action, thereby giving the patient a degree of comfort that will be thoroughly appreciated.

Quinine Inunctions and Solutions. When quinine is not well borne by the stomach, and

particularly in treating children J. F. Conner (Eclectic Med. Journ.) says that most excellent results are obtainable from an inunction of quinine and lard or petrolatum. One dram of the powdered quinine rubbed up with two drams of the lard or vaseline, and freely applied to the axilla, groin and abdomen, will act well. In the treatment of hay fever an ointment consisting of quinine and vaseline in the proportion of 30 grains to the ounce, applied to the mucous membrane of the nares every four or six hours, together with the employment of a saturated solution of quinine in sterilized water as a nasal spray, will produce excellent results. An application at bedtime and at 2 o'clock will prevent all symptoms of coryza during the night.

Sulphate of quinine, in solution, has proved a valuable application to indolent ulcers, buboes, chancres, and chronic mucous inflammations. It is often of service in diphtheria, being applied locally to the membrane, and in gonorrhea it has done good service by injecting it into the urethra. Locally applied, in follicular conjunctivitis and trachoma, it will occasionally give relief to the patient. The solution may be made as follows:

Quinine sulphate, 3i; essence of orange (prepared by covering the outer layer of fresh orangepeel with dilute alcohol), 3i; hydrochloric acid, a few drops to effect solution; water, viij. Mix. Dose, one teaspoonful in a wineglassful of cold water, as a tonic, when quinine is indicated. 惺惺惺

An uneducated Scotchman made a fortune. One day he and an acquaintance were talking when the latter said to old Duncan.

"Say, Duncan, you don't know enough to go in when it rains. Why, you can't even spell 'bird.''

"B-u-r-d," said Duncan.

"I tell you you don't know anything. Why, if you had to spell to make a living you'd have been dead years ago. I'll bet you a hundred you can't spell 'bird.'"'

"I'll tak' ye," quickly replied Duncan. After the money was put up, Duncan said, "B-i-r-d."

"That ain't the way you spelled it the first time."

"I wasna bettin' then."

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Volume XXXVII. Number 12.

The

Medical Standard

DECEMBER 1914

TYPHOID EPIDEMIC TRACED TO A
CARRIER.

One of the most interesting illustrations of the danger of typhoid fever being transmitted by carriers has recently been presented in the Journal of the American Medical Association. A church dinner was held in a small California town, meals being served at noon and again in the evening. About 150 people took part in these two repasts. Within three days a case of typhoid fever developed in town and others appeared in rapid succession. In all, 93 people suffered from the disease; of these, 85 were at one or other of the meals served by the church, and the remaining 8 had partaken of the same food, which had been brought them by friends in attendance.

A careful investigation of this epidemic was made by a representative of the state board of health, in connection with the state hygienic laboratory. It was suspected that some person who had something to do with the preparation or serving of the meal was a carrier, and a careful study was made of the local situation in order to find

out who that person was. The responsibility was finally fixed upon a woman of 62. She was not sick, nor had she been sick recently. The evidence showed that she had probably suffered from typhoid fever more than twenty-five years before; also, that there had been four cases of the disease among boarders in her family within the last eight years, two of these within the preceding two years. While this lady had helped serve the dinner, and had worked some in the kitchen, she had really been much less active than the majority of the ladies of the congregation similarly engaged.

The medium by which the infectious material was conveyed was finally shown to be a large dish of spaghetti which this woman had prepared. This was made up the day before the dinner at her home, but with the cooking of the dish she had nothing whatever to do. Her connection with

the spaghetti stopped with its preparation for the oven. The question which immediately was raised was as to the possibility of the typhoid bacteria resisting the high temperature employed in baking. A similar but smaller quantity of spaghetti was prepared in the state laboratory in exactly the same manner and according to the same recipe employed by the lady who prepared the dish to serve at the dinner. It was baked in the same way. Cultures taken from this dish showed that the browned surface was bacteriafree, but a few cultures were found within an inch of the top of the dish, while two inches from the top the micro-organisms were present in abundance.

This case again shows that typhoid fever is an ever-present danger. We have not yet forgotten an epidemic of the disease here in Chicago, which was traced to a cook in a down-town restaurant, nor the epidemic occurring among persons who made an excursion trip on a Lake Erie steamship, which was also traced to a worker in the kitchen. The more we learn about typhoid fever, the more we become convinced that the human factor is the most important one and the most difficult one with which we have to deal. The mere fact that the people who handle the food we eat in restaurants, on railroads and steamships, in grocery stores, in meat shops, and on milk wagons are apparently in good health gives us no assurance whatever that they may not convey this or some other plague.

Nor does cooking protect us. If bacteria can linger in the midst of baked macaroni paste, then they may be present in our steamed oysters, our puddings, our gravies, possibly even in our bread. We hold our tenure of health and even life by a slender thread, which the growingly complex tools of civilization are spinning out to an ever increasing tenuity. Yet-as we learn the perils of life, we are also learning better methods of overcoming them.

HOOF AND MOUTH DISEASE. reach around the world. The newspapers give There have been so many articles, so many edi- us vivid pictures of what people are doing in torials, regarding hoof and mouth disease that it every corner of the earth; our hearts are tuned is not necessary to tell the readers of the STAND- to others' suffering and are thrilled by others' ARD what it is, nor describe its dangers to man heroism. In our own homes we can hear Caruso and beast. It is known to be an intensely con- sing or Paderewski play. At vacation time we are tagious disease, and the readiness with which it whirled across the continent, perhaps carried beis transmitted makes it vitally important that every yond the ocean, in half the time it took our piocase should be immediately recognized so that neer ancestor to drive his ox-team through the every focus may be immediately destroyed. A passes of the Alleghanies to the rich valleys besingle focus remaining means that sooner or later yond. Every day we eat food that comes from the there will be another general epidemic, with the wheat fields of Manitoba, the orange-groves of danger of the disease eventually becoming en- Florida, the rice-paddies of China, the steaming demic in America as it is in Europe. hillsides of Ceylon, the beet fields of Germany, and the fat pastures of Holland. Our own surplus, loaded into a thousand ships, feeds, and clothes, and transports, and otherwise works for people speaking a hundred tongues.

That this is a very real danger has been shown by the discovery that foot and mouth disease has been transmitted by the serum used for the prevention of hog cholera. A Chicago firm making this serum used in its preparation hogs obtained from the stockyards which were subsequently found to be infected with the foot and mouth contagion. Innocently enough this firm sent supplies of serum to their customers at a number of points remote from Chicago. As a result, cases of the disease were soon reported as occurring among various groups of hogs in the central west who had been injected against hog cholera. The manufacture of hog-cholera serum by the Chicago firm was, of course, prohibited at once by the Government, and its stock of the remedy was destroyed. This experience illustrates the difficulty of the problem which the Bureau of Animal Industry and the various state officials are being called upon to deal with. They need the earnest co-operation of every physician, for aside from the possibility of human infection, there is the economic disaster to be reckoned with. Every one who produces meat, or consumes it, is affected by this disease, which has within itself the possibilities of a great national disaster.

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OUR COMPLEX CIVILIZATION. Our grandfathers got along quite comfortably without many of the advantages of our modern civilization, and never knew what they missed. The truth is that with the "advantages" they also missed many perils. In the old days men touched hands only with their fellows-the people in the same town or the same county, only rarely with those living at more remote distances. As a result, their vision was much narrower than ours is supposed to be at the present time, yet if they could not look quite so far afield the thoughtful men still had enough to think about, and possibly more time to do their thinking in, than we have

now.

And the result of it all-one result of it--is that whatever benefits any of these far-away men and women benefits us also; and any evil that imperils them, tomorrow may be knocking at our door.

In Indiana an observant veterinarian finds a cow with strange looking vesicles above the hoof and around the mouth. It is the "new" disease. The farmer bought that cow in Chicago, and the packer purchased it from a man in Michigan. In a fortnight an inconsequential local ailment, of a cow, too slight to attract attention, has become a great national plague, throwing thousands out of work, crippling a dozen industries, and threatening the health of human beings in all parts of the country. In the old days the disease would have attracted no attention. Perhaps it would have died out in time on the very farm on which it first made its appearance; perhaps it would have swept over a state or county.

Nothing that we do or can do is longer inconsequential. The machine has become too complex, and even the breaking of a single cog may put the whole mechanism out of gear with disastrous consequences to millions. Civilization, as we call it, is able to more than overcome the perils lying all around because of the perfection of the machine but one little flaw in one of its millions of parts may bring disaster much more for-reaching than was possible under the old regime. For instance, war, we thought, was impossible. Yet we have found that the peace which we thought so secure as to seem perpetual rested on the whims and fancies of a few feeble men, who were called diplomats. A sluggish liver and a word spoken in passion and in pride-and the peace-machine went to pieces.

The moral of it all is, that if human "progress" In these modern days our outstretched fingers is to bring happiness or betterment to mankind,

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