The Origins of Genome Architecture
Sinauer Associates, 2007 - 494 страници
With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter. Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.
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The Stem Eukaryote
Genome Size and Complexity
Population Size and the Mutational Hazard of Excess DNA
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Acad allele ancestral animals autosomes average Biol Caenorhabditis cell cellular centromeric cerevisiae Chapter chromosome coding codon complex copy deleterious mutations denote divergence Drosophila duplicate genes effective population effective population size elegans endosymbiont estimates eukaryotes Evol evolutionary evolve exon expected Figure fixation frequency functional gene conversion gene duplication gene expression genomic evolution group II introns host human genome hypothesis initiation insertions intergenic land plants lineages locus Lynch mammalian mammals mechanisms melanogaster mitochondrial genomes mobile elements molecular mRNA multicellular species muta mutation rate Natl natural selection neutral non-LTR noncoding noncoding DNA nuclear genome nucleotide observations organelle organelle genomes origin pair patterns phylogenetic polyploidization population genetic Proc prokaryotes protein-coding genes proteins pseudogenes random genetic drift recombination regions regulatory replication retrotransposons ribosomal sequence silent sites spliceosomal stem eukaryote strand subfunctionalization telomere tion trans transcription factor transposons tRNA unicellular species upstream variation vertebrates yeast